Associate Scientist, Pharmacology

Translational Sciences · Seattle, Washington
Department Translational Sciences
Employment Type Permanent - Full Time
Minimum Experience Experienced

Zymeworks is a clinical-stage biopharmaceutical company dedicated to the discovery, development and commercialization of next-generation bispecific and multifunctional biotherapeutics, initially focused on the treatment of cancer. Zymeworks’ suite of complementary therapeutic platforms and its fully-integrated drug development engine provide the flexibility and compatibility to precisely engineer and develop highly-differentiated product candidates.

Zymeworks is seeking an Associate Scientist to join the Pharmacology team within the Translational Sciences group to assess the therapeutic potential of pipeline candidates in in vivo immuno-oncology experiments. The successful candidate will join a growing, highly motivated team dedicated to advancing novel therapeutics from early phase through preclinical development. 


This position reports to a Senior Scientist, Pharmacology and will be based in Seattle, WA.

Roles and Responsibilities

  • Plans and manages the execution of in vivo immuno-oncology efficacy and PD experiments in collaboration with project team representatives.
  • Evaluates emerging technologies, develops new in vivo models and establishes protocols.
  • Analyzes data using software including Excel, GraphPad Prism, FlowJo and authors electronic lab notebook.
  • Provides leadership, mentorship, and scientific/technical guidance to junior staff.
  • Summarizes and presents results to supervisor in a logical manner, verbally and in written reports or presentations. May present data to project team meetings.


Qualifications and Experience

  • MSc in a scientific discipline in biological sciences and a minimum of 7 years of related experience or an equivalent combination of education and experience.
  • Expertise in running xenograft, syngeneic, or humanized mouse tumor models and in mammalian cell culture.
  • Expertise in planning and executing in vivo pharmacology studies to evaluate efficacy, pharmacokinetics, pharmacodynamics, tolerability, and mechanism of action.
  • Direct experience analyzing ex vivo samples by multi-color flow cytometry.
  • Proven interpersonal skills with the ability to work collaboratively as a member of a cross-functional scientific project.
  • Experience initiating & designing operations/protocols in a new in vivo facility is desired.
  • Proficient in animal handling, dosing (SC, IP, IV), collection of blood and tumor samples.


Why Work for Us?


Innovation. Act with Integrity. Collaboration. Care

Zymeworks’ employees are passionate, engaged and extremely motivated to succeed.  We are excited by the cutting-edge science and technology, the endless possibilities this union holds and the sheer opportunity to be a part of something big.  To learn more about Zymeworks Inc. and our current openings, please visit our website at

We offer challenging career opportunities, competitive benefits and an environment that recognizes and rewards performance.


NOTE TO EMPLOYMENT AGENCIES: Zymeworks values our relationships with our Recruitment Partners. We will only accept resumes from those partners whom have been contracted by a member of our Human Resources team to collaborate with us. Zymeworks is not responsible for any fees related to resumes that are unsolicited or are received without contract.

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  • Location
    Seattle, Washington
  • Department
    Translational Sciences
  • Employment Type
    Permanent - Full Time
  • Minimum Experience