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Zymeworks Inc

Scientist (Senior), Pharmacology

Translational Sciences · Seattle, Washington
Department Translational Sciences
Employment Type Permanent - Full Time
Minimum Experience Experienced

Zymeworks is a clinical-stage biopharmaceutical company dedicated to the discovery, development and commercialization of next-generation bispecific and multifunctional best-in-class biotherapeutics.  Zymeworks’ suite of complementary therapeutic platforms and its fully-integrated drug development engine provide the flexibility and compatibility to precisely engineer and develop highly-differentiated product candidates.


Zymeworks is seeking a scientist/senior scientist to join the Pharmacology team within the Translational Sciences group to assess the therapeutic potential of pipeline candidates in preclinical in vivo immuno-oncology experiments. The successful candidate will be part of a dynamic and highly motivated team responsible for supporting pipeline project advancement. The candidate will be challenged to design experiments, manage the execution of studies, and critically analyze results. 


This position reports to a Principal Scientist, Pharmacology and will be based in Seattle, WA. 


Roles and Responsibilities

  • Represents Pharmacology group on immuno-oncology pipeline project teams from hit-to-lead through preclinical development. 
  • Designs, manages, executes, and analyzes in vivo immuno-oncology experiments to assess efficacy and establish PK/PD relationships.
  • Develops strategic plans of pharmacology experiments on immuno-oncology pipeline project teams in collaboration with project team.
  • Presents data from in vivo experiments to project teams and Pharmacology group.
  • Actively works to foster an environment of effective and collaborative working relationships amongst employees, management and external partners.
  • Provides input into and champions/adheres to best practices and timelines.
  • Authors electronic lab notebook, reports, and contributes to writing sections of regulatory documents.
  • Provides leadership, mentorship and scientific/technical guidance to technical staff.


Qualifications and Experience

  • PhD in immunology, pharmacology, cancer biology, or a related scientific discipline and a minimum of 2 to 5 years related experience.
  • Direct experience performing immuno-oncology in vivo experiments in syngeneic models and humanized mouse models.
  • Understanding and direct experience of ex vivo immune cell analysis by multi-color flow cytometry.
  • Proven interpersonal skills with the ability to work collaboratively as a member of a cross-functional scientific project. 
  • Clear and effective oral communication and scientific/technical writing skills. Ability to present data at team meetings and interdepartmental meetings.
  • Experience initiating & designing operations/protocols in a new in vivo facility is desired. 


Why Work for Us?

Zymeworks’ employees are passionate, engaged and extremely motivated to succeed.  We are excited by the cutting-edge science and technology, the endless possibilities this union holds and the sheer opportunity to be a part of something big.  To learn more about Zymeworks Inc. and our current openings, please visit our website at www.zymeworks.com. 


We offer challenging career opportunities, competitive benefits and an environment that recognizes and rewards performance. 


NOTE TO EMPLOYMENT AGENCIES: Zymeworks values our relationships with our Recruitment Partners. We will only accept resumes from those partners whom have been contracted by a member of our Human Resources team to collaborate with us. Zymeworks is not responsible for any fees related to resumes that are unsolicited or are received without contract.


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  • Location
    Seattle, Washington
  • Department
    Translational Sciences
  • Employment Type
    Permanent - Full Time
  • Minimum Experience